HCID 18997185, compound → HCID 54476680, compound

HRID 374512Notes

Reaction equation

HRID 374512 reaction equation
[C:1]1([N:7]2[CH2:11][CH:10]([CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][C:22](OC)=[O:23])=[CH:16][CH:15]=3)[O:9][C:8]2=[O:26])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C=CC(N2CC(COC3C=CC(CCC(OC)=O)=CC=3)OC2=O)=CC=1>>[C:1]1([N:7]2[CH2:11][CH:10]([CH2:12][O:13][C:14]3[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][CH2:22][OH:23])=[CH:18][CH:19]=3)[O:9][C:8]2=[O:26])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 18997185HCID 18997185, compoundHCID 18997213HCID 18997213, compound2×

Product 1

HCID 54476680HCID 54476680, compoundYield 48%

Procedure

The same procedure of Example 34 was repeated except that methyl 3-[4-(3-phenyl-2-oxooxazolidin-5-yl)methoxyphenyl]propionate (compound 189) obtained in Example 31 was used in lieu of methyl 3-{4-[3-(4-chlorophenyl)-2-oxooxazolidin-5-yl]methoxyphenyl}propionate to give the title compound (compound 195) in a yield of 48%.

Workup

  1. customobtained in Example 31

Sources & evidence

ORD record
ord-742dceb7366144cca3746a3d7908c937
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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