Triethylamine → HCID 19419287, Verbindung

HRID 374527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374527
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:19](=O)O[CH:17]([C:21]([F:24])([F:23])[F:22])[N:16]=2)=[CH:11][CH:10]=1.[N+:25]([C:28]1[S:29][C:30]([CH:33]=C[N+]([O-])=O)=[CH:31][CH:32]=1)([O-:27])=[O:26]>C(#N)C>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:16][C:17]([C:21]([F:24])([F:23])[F:22])=[C:33]([C:30]3[S:29][C:28]([N+:25]([O-:27])=[O:26])=[CH:32][CH:31]=3)[CH:19]=2)=[CH:11][CH:10]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 110652915(2H)-Oxazolone, 4-(4-chlorophenyl)-2-(trifluoromethyl)-HCID 542116852-Nitro-5-(2-nitrovinyl)thiophene

Produkt 1

HCID 19419287HCID 19419287, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Triethylamine (1.16 g, 11.3 mmol) is added to a solution of 4-(p-chlorophenyl)-2-(trifluoromethyl)-3-oxazolin-5-one (2.97 g, 11.3 mmol) and 2-nitro-5-(2-nitrovinyl)thiophene (2.26 g, 11.3 mmol) in acetonitrile near reflux. The reaction mixture is refluxed for one hour, stirred overnight at room temperature and concentrated in vacuo to obtain a red oil. Chromatography of the oil gives the title product as a tan solid, mp 166°-169° C.

Aufarbeitung

  1. temperaturenear reflux
  2. temperatureThe reaction mixture is refluxed for one hour
  3. concentrationconcentrated in vacuo
  4. customto obtain a red oil

Quellen und Nachweise

ORD-Eintrag
ord-8847ac0d540e4109a80abfdd7ccdb957
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05480902

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