Water → HCID 18987447, compound

HRID 374531Notes

Reaction equation

HRID 374531 reaction equation
[Br:1][C:2]1[S:6][CH:5]=[C:4]([C:7]2[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[NH:9][C:8]=2[C:22]([F:25])([F:24])[F:23])[CH:3]=1.[Br:26]Br.C([O-])(=O)C.[Na+].O>C(O)(=O)C>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([C:10]2[NH:9][C:8]([C:22]([F:23])([F:24])[F:25])=[C:7]([C:4]3[C:3]([Br:26])=[C:2]([Br:1])[S:6][CH:5]=3)[C:11]=2[N+:12]([O-:14])=[O:13])=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24408BromineHCID 517045Sodium AcetateHCID 19419275HCID 19419275, compound

Product 1

HCID 18987447HCID 18987447, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3-(5-bromo-3-thienyl)-5-(p-chlorophenyl)-4-nitro-2-(trifluoromethyl)pyrrole (0.50 g, 1.1 mmol), bromine (0.20 g, 1.3 mmol) and sodium acetate (0.11 g, 1.3 mmol) in acetic acid (10 mL) is heated overnight at 50° C. and poured into water. The solids are collected and recrystallized from 1,2-dichloroethane to give the title product as a yellow solid, mp 241°-242° C.

Workup

  1. customThe solids are collected
  2. customrecrystallized from 1,2-dichloroethane

Sources & evidence

ORD record
ord-3295a1607a234cf68e7df77d6380d922
Source dataset
uspto-grants-1996_01
Patent number
US05480902

Reaction notes

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