Acetic Acid → HCID 18997246, compound

Participants

Reaction Steps

A solution of 3.5 g of intermediate (2) and 4.72 g of 2,6-dichlorobenzaldehyde in 100 ml of acetic acid was stirred for 2 hours at room temperature. 1.75 g of potassium cyanide was added and after stirring for 20 hours at room temperature, the reaction mixture was poured into water. The precipitated product was filtered off, washed with water and recrystallized from 2-propanol. The product was filtered off and dried, yielding 6 g (83.5%) of (±)-α-[(6-acetyl-2,3-dihydro-1H-inden-5-yl)amino]-2,6-dichlorobenzeneacetonitrile (interm. 17).

Provenance & Evidence