Thiophene → HCID 18997248, compound

Participants

Reaction Steps

2-methyl-2-(2-nitrophenyl)- 1,3-dioxolane (0.132 mol) was dissolved in tetrahydrofuran (600 ml) and this solution was hydrogenated with platinum on activated carbon (4 g) as a catalyst in the presence of calcium oxide (10 g) and thiophene (3 ml). After uptake of H2 (3 equiv), the catalyst was filtered on celite and washed with tetrahydrofuran. The flitrate was evaporated. The residue was recrystallized from n-hexane. The crystals were filtered off and dried, yielding 18.5g (78%) of 2-(2-methyl-1,3-dioxolan-2-yl)benzenamine (interm. 27).

Provenance & Evidence