HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine | HCID 10856960 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride | HCID 22857293 | — |
Reaction Steps
26 g (0.11 mol, 92% strength) of cis-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are hydrogenated on 3 g of palladium/active charcoal (10% Pd) at 100° C. and 100 bar H2 in 180 ml of ethanol and 19 ml of concentrated hydrochloric acid. The catalyst is filtered off with suction, the filtrate is concentrated and the crystals which have separated out are dried in a desiccator over phosphorus pentoxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05480879 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-ccf30365f6c34b6d8d579e5f4381522a |
| Source note | uspto-grants-1996_01 |