HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 6-(Methylamino)pyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-[(Dimethylamino)methylidene]pent-2-enedinitrile | HCID 3730892 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(Methylamino)pyridine-3-carbonitrile | HCID 17860899 | — |
Reaction Steps
7.4 g of dimethylaminomethylene-glutacononitrile, 100 ml of DMF and 4.4 g of 35.6% strength aqueous methylamine solution were held for 2 hours at 80° C. in an 0.3 l V4A autoclave. After the mixture had been removed and concentrated, 6.4 g of 2-methylamino-5-cyanopyridine (purity 93%) were obtained, which corresponds to 90.2% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05480995 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-c0ad1f8d48b14744ae5ce323da9b4292 |
| Source note | uspto-grants-1996_01 |