反应详情

In the 20 ml of acetone was dissolved 3,5-dimethyl-5-trifluoromethyl-4-hydroxy-2-cyclohexen-1-one(A-4) prepared in Example 5, and 6.2 ml of Jones reagent was added dropwise. Then, the mixture was stirred for 10 minutes, was added dropwise to 10 ml of methyl alcohol and stirred for 30 minutes. The reaction mixture was filtered to remove the filtrate. The residue thus obtained was fractionated with column chromatography using n-hexane/ethyl acetate(4:1, v/v) as eluent to give 2.74 g of the title compound(yield: 86.4%).

1. additionwas added dropwise
2. stirringstirred for 30 minutes
3. filtrationThe reaction mixture was filtered
4. customto remove the filtrate
5. customThe residue thus obtained