反应详情

2.64 g (12.8 mmole) of 3,5-dimethyl-5-trifluoromethyl-2-cyclohexen- 1,4-dione(A-5) prepared in Example 6 and 1.59 g (25.6 mmole) ethylene glycol were mixed with 250 ml of toluene, and 0.1 g of p-toluenesulfonic acid was added as catalyst. After cooling to room temperature, the reaction mixture was washed with water and aqueous solution of sodium bicarbonate. The organic layer thus formed was dried using anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was fractionated with column chromatography using n-hexane/ethyl acetate(5:1, v/v) as eluent to produce the title compound(yield: 90.6%).

1. additionwas added as catalyst
2. washthe reaction mixture was washed with water and aqueous solution of sodium bicarbonate
3. customThe organic layer thus formed
4. customwas dried
5. customthe solvent was evaporated under reduced pressure