HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-Benzyl-2-bromo-N-methylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Benzyl-2-bromo-N-methylacetamide | HCID 150681 | 100.1% |
Reaction Steps
At 0° C., a solution of 10 g of bromoacetyl bromide in 20 ml of DCM is added to a solution of 6 g of methylbenzylamine and 5g of triethylamine in 50 ml of DCM. After one night at RT, ether is added, the precipitate formed is filtered off and the filtrate is concentrated to give 12 g of the expected product in crude form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05481005 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-34a12460b3c14aa8b4a83664edd007bf |
| Source note | uspto-grants-1996_01 |