Acetone → Methyl 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

Participants

Reaction Steps

A mixture of 9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid (28.4 g), dimethyl sulphate (59 ml; 79 g) and anhydrous potassium carbonate (207 g) in `Drierire` dried acetone (1350 ml) and dioxan (1200 ml) was heated at reflux for 17 hours, with mechanical stirring. After allowing to cool, the suspension was filtered and the filter contents were washed with hot dioxan (5×50 ml).

Provenance & Evidence