反应详情

温度

-10 °C

In 13 ml of acetic anhydride was suspended 5.0 g of 3,4-diethoxycarbonyl-6-phenyl-2-pyridone; and the suspension was cooled to -10° C. Fuming nitric acid (1.32 ml; 2.0 eq.) was added dropwise over 1 hour, and the mixture was stirred for 45 minutes as it is. After 40 ml of water was added, the mixture was stirred at room temperature and left standing overnight. The resulting crystals were collected by filtration and dried. Yield: 4.61 g (80.7%). The crystals were recrystallized from ethanol, to give pale yellow needles.

1. stirringthe mixture was stirred at room temperature
2. waitleft
3. waitstanding overnight
4. filtrationThe resulting crystals were collected by filtration
5. customdried
6. customThe crystals were recrystallized from ethanol
7. customto give pale yellow needles