HCID 15708223, compound → HCID 11805344, compound

HRID 374721Notes

Reaction equation

HRID 374721 reaction equation
[CH2:1]([C@H:8]([CH2:12][O:13]CC1C=CC=CC=1)[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([C@H:8]([CH2:12][OH:13])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 15708223HCID 15708223, compound

Product 1

HCID 11805344HCID 11805344, compoundYield 103.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

420 mg of (2R)-2-benzyl-3-benzyloxypropionic acid was dissolved in 5.5 ml of ethanol, and hydrogenated at an ordinary temperature under an atmospheric pressure for two hours in the presence of palladium black. The insolubles were removed by filtration, and then the solvent was distilled off under reduced pressure to obtain 290 mg of (2R)-2-benzyl-3-hydroxypropionic acid as colorless oily substance.

Workup

  1. customThe insolubles were removed by filtration
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-5887c2671b4a4abcb958225e743e833f
Source dataset
uspto-grants-1996_01
Patent number
US05481036

Reaction notes

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