反应详情

27 mg of (6-hydroxy-2-cyclohexylbenzo[b]thien-3yl)[4[2-(1-piperidinyl)ethoxy]phenyl]methanone is dissolved in 1 mL of pyridine, 0.1 mL of benzoyl chloride is added, and this mixture is agitated for one hour at room temperature. Ice is added to the reaction mixture, and the system is agitated for one hour. The organic layer is extracted with ethyl acetate and dried with anhydrous magnesium sulfate. The solvent is distilled off, and the crude product thus obtained is refined by TLC (developing solvent was chloroform:methanol=9:1), which gives 37 mg of (6-benzoyloxy-2-cyclohexylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone.

1. additionIce is added to the reaction mixture
2. stirringthe system is agitated for one hour
3. extractionThe organic layer is extracted with ethyl acetate
4. dry with materialdried with anhydrous magnesium sulfate
5. distillationThe solvent is distilled off
6. customthe crude product thus obtained