Triethylamine → 2-(2,2,2-Trifluoroethyl)-2-(trifluoromethyl)-1,3-benzodioxole

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Reaction Steps

306.5 g of 2-(1-chloro-2,2,2-trifluoroethyl)-2-trifluoromethyl-1,3-benzodioxole from Example 2 were dissolved in 500 ml of THF, and 101 g of triethylamine and 30 g of palladium-on-charcoal (5% strength by weight) were added. The starting substance was then hydrogenated with 100 bar of hydrogen at 110° C. for 48 h. The mixture was then filtered, the solvent was stripped off and the residue was fractionated in vacuo. The yield was 126 g (46% of theory), and the boiling point was 60° C. under 10 mbar.

Provenance & Evidence