Carbamic acid, [(1,1-dimethylethyl)carbonimidoyl]-, methyl ester → HCID 54535399, compound

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Reaction Steps

A mixture of [2-(5-bromo-naphthalen-2-ylmethyl)-3-oxo-cyclohex-1-enyl]-acetic acid (1.1 g, 2.95 mmol), N-methoxycarbonyl-N'-tert-butylcarbodiimide (0.51 g, 3.25 mmol), and THF (20 mL) was refluxed for 4 hours. The volatiles were removed in vacuo and the residue was purified by flash chromatography on silica gel (eluting solvent hexane/EtOAc 2/1 ) to give a white solid (0.95 g, 76% yield, m.p. 128°-129° C.).

Provenance & Evidence