反应详情

3 g of Raney nickel are added to 23.9 g (0.112 mol) of 4'-methyl-2-nitrobiphenyl (R. B. Muller and S. Dugar, Organometallics 1984, 3, 1261) in 50 ml of methanol and the mixture is hydrogenated under normal pressure at room temperature until the theoretical amount of H2 has been absorbed. The catalyst is then removed by filtration and the filtrate is concentrated. Chromatography on SiO2 (500 g) using EA/HEP(1:6) as the eluent yields 19 g of the title compound as an oil (92.5%)

1. customis hydrogenated under normal pressure at room temperature until the theoretical amount of H2
2. customhas been absorbed
3. customThe catalyst is then removed by filtration
4. concentrationthe filtrate is concentrated