HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 374885Generated: October 30, 2026
Sodium Dithionite → Ethyl 2-amino-2-cyanoacetate
https://huagongshe.com/reaction/374885
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | Ethyl 2-cyano-2-(hydroxyimino)acetate | HCID 6399078 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | Ethyl 2-amino-2-cyanoacetate | HCID 288716 | 37.4% |
Reaction Steps
119 g of sodium dithionite are added in portions (15 min) at room temperature to 35 g (0.246 mol) of ethyl 2-cyanoglyoxylate-2-oxime in 350 ml of H2O and 280 ml of saturated sodium hydrogen carbonate solution. The mixture is then warmed at 35° C. for 1 hour; it is then saturated with NaCl and extracted 5 times with dichloromethane. After drying with calcium chloride, the organic phase is concentrated. 11.8 g of the title compound are obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05482957 |
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| Source dataset | uspto-grants-1996_01 |
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| ORD ID | ord-235fc25abea847fa96cceaa33bd6c79f |
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| Source note | uspto-grants-1996_01 |
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