HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 6-(2-(5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,4-benzodioxan-2-yl-thiomethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium bisulfide | HCID 102109 | — |
| Reactant | 3-Chloromethyl-6-(2-(5-(3-chloro-phenyl)-2-oxo-3-oxazolidinyl)propyl)-1,4-benzodioxane | HCID 54265284 | — |
| Product | 6-(2-(5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,4-benzodioxan-2-yl-thiomethanol | HCID 18996366 | — |
Reaction Steps
One equivalent of product from Example 6, 2-isomer, and 2 equivalents of potassium hydrosulfide in dimethylsulfoxide is heated at 60° C. for 8 hours. The reaction mixture is poured into water, the precipitated product is collected and recrystallized from ethyl alcohol to give 6-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,4-benzodioxan-2-yl-thiomethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05482971 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-27f2f83ee43e4e299ab0c6d381927da5 |
| Source note | uspto-grants-1996_01 |