HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 374890Generated: October 25, 2026
Water → 6-(2-(5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-3-methylthiomethyl-1,4-benzodioxane
https://huagongshe.com/reaction/374890
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 3-Chloromethyl-6-(2-(5-(3-chloro-phenyl)-2-oxo-3-oxazolidinyl)propyl)-1,4-benzodioxane | HCID 54265284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(2-(5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-3-methylthiomethyl-1,4-benzodioxane | HCID 18996331 | — |
Reaction Steps
One equivalent of product from Example 6, 3-isomer, and 2 equivalents of sodium methyl mercaptide in dimethylformamide, containing a catalytic amount of potassium iodide, is stirred at 60° C. for 18 hours. The mixture is poured into water, the resulting product is collected and recrystallized from ethyl alcohol to give 6-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-3-methylthiomethyl-1,4-benzodioxane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05482971 |
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| Source dataset | uspto-grants-1996_01 |
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| ORD ID | ord-39fea4d777554a6fa1133d296ad07661 |
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| Source note | uspto-grants-1996_01 |
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