2,5-Dibromothiazole → HCID 18996158, compound

HRID 374940Notes

Reaction equation

HRID 374940 reaction equation
[CH3:1][C:2]1([C:7]2[CH:14]=[CH:13][C:10]([CH2:11][OH:12])=[CH:9][CH:8]=2)[O:6][CH2:5][CH2:4][O:3]1.Br[C:16]1[S:17][C:18]([Br:21])=[CH:19][N:20]=1>>[CH2:4]1[O:3][C:2]([C:7]2[CH:14]=[CH:13][C:10]([CH2:11][O:12][C:16]3[S:17][C:18]([Br:21])=[CH:19][N:20]=3)=[CH:9][CH:8]=2)([CH3:1])[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 3123942,5-DibromothiazoleHCID 21809009HCID 21809009, compound

Product 1

HCID 18996158HCID 18996158, compoundYield 60%

Procedure

Using an analogous procedure to that described in the first paragraph of the portion of Example 43 which is concerned with the preparation of starting materials, 4-(2-methyl-1,3-dioxolan-2-yl)benzyl alcohol was reacted with 2,5-dibromothiazole to give 4'-(5-bromothiazole-2-yloxymethyl)acetophenone ethylene acetal in 60% yield as an oil.

Sources & evidence

ORD record
ord-a37da4bbccf14e768885c725330028e2
Source dataset
uspto-grants-1996_01
Patent number
US05482966

Reaction notes

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