Benzylamine → HCID 54552295, compound

HRID 374990Notes

Reaction equation

HRID 374990 reaction equation
[CH3:1][N:2]1[C:11]([CH2:12][C:13](O)=[O:14])=[C:10]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][C:6]([CH3:23])=[C:7]([CH3:22])[CH:8]=2)[C:3]1=[O:24].[CH2:25]([NH2:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([NH:32][C:13](=[O:14])[CH2:12][C:11]1[N:2]([CH3:1])[C:3](=[O:24])[C:4]2[C:9]([C:10]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:8][C:7]([CH3:22])=[C:6]([CH3:23])[CH:5]=2)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 21463115HCID 21463115, compound

Product 1

HCID 54552295HCID 54552295, compound

Procedure

1,2-Dihydro-2,6,7-trimethyl-1-oxo-4-phenyl-3-isoquinolineacetic acid (Reference Example 56) and benzylamine were reacted (amidation) and treated in substantially the same manner as in Example 101 to yield the title compound as colorless crystals.

Workup

  1. additiontreated in substantially the same manner as in Example 101

Sources & evidence

ORD record
ord-896680ad543d443d9e0cf745370872d3
Source dataset
uspto-grants-1996_01
Patent number
US05482967

Reaction notes

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