3,5-Bis(trifluoromethyl)benzylamine → HCID 21463193, compound

HRID 374992Notes

Reaction equation

HRID 374992 reaction equation
[O:1]=[C:2]1[C:11]([C:12](O)=[O:13])=[C:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[F:21][C:22]([F:36])([F:35])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:26][NH2:27]>>[F:21][C:22]([F:35])([F:36])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:30]=1)[CH2:26][NH:27][C:12]([C:11]1[C:2](=[O:1])[NH:3][C:4]2[C:9]([C:10]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:13]

Participants

3

Reactant 2

HCID 5210993,5-Bis(trifluoromethyl)benzylamineHCID 151627412-Oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid

Product 1

HCID 21463193HCID 21463193, compound

Procedure

1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarboxylic acid was reacted with 3,5-bis(trifluoromethyl)benzylamine by a method similar to Example 101 (amidation) to yield the title compound.

Sources & evidence

ORD record
ord-1ef53216e21f4c738bb3903928e17045
Source dataset
uspto-grants-1996_01
Patent number
US05482967

Reaction notes

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