反应详情

To a solution of the compound obtained in Example 269 (100 mg) in ethanol (4 ml) was added 40% MeNH2 -methanol (12 ml), and the mixture was stirred for 4 hours with heating under reflux. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried and evaporated to yield the title compound as colorless crystals (65 mg).

1. temperaturewith heating
2. temperatureunder reflux
3. customThe solvent was evaporated
4. dissolutionthe residue was dissolved in ethyl acetate
5. washThe solution was washed with water
6. customdried
7. customevaporated