反应详情

Phenylglyoxal monohydrate (304 mg, 2 mM) and ethylbenzene (0.49 ml, 4 mM) were dissolved in dichloroethane (4 ml), titanium tetrachloride (0.33 ml, 3 mM) was added, and reacted at room temperature for 2 hours. The reaction mixture was extracted with ethylacetate, the extract was washed with saturated sodium hydrogen carbonate solution and brine, dried with sodium sulfate anhydrous, and then concentrated to obtain a yellow-colored oil. The oil was crystallized from a petroleum ether/diethylether to obtain 357.1 mg (74.0% yield) of 4'-ethylbenzoin.

1. customreacted at room temperature for 2 hours
2. extractionThe reaction mixture was extracted with ethylacetate
3. washthe extract was washed with saturated sodium hydrogen carbonate solution and brine
4. dry with materialdried with sodium sulfate anhydrous
5. concentrationconcentrated
6. customto obtain a yellow-colored oil
7. customThe oil was crystallized from a petroleum ether/diethylether