P-Xylene → HCID 18994047, compound

HRID 375047Notes

Reaction equation

HRID 375047 reaction equation
O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1>ClC(Cl)C.[Ti](Cl)(Cl)(Cl)Cl>[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][C:18]=1[CH:10]([OH:11])[C:8](=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7809P-XyleneHCID 12215922Glyoxal, phenyl-, hydrate

Product 1

HCID 18994047HCID 18994047, compound

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 63651,1-DichloroethaneSolvent

Procedure

Phenylglyoxal monohydrate (500 mg, 3.29 mM) and p-xylene (0.56 ml, 4.79 mM) were dissolved in dichloroethane (5 ml), titanium tetrachloride (0.9 ml, 8.2 mM) was added, and reacted at room temperature for 30 minutes. Using the same procedure as in Example 1, 2',5'-dimethylbenzoin was obtained as crystal (587.7 mg, 73.9% yield).

Workup

  1. customreacted at room temperature for 30 minutes

Sources & evidence

ORD record
ord-235b17a21ecf454d9b2b65049468ef13
Source dataset
uspto-grants-1996_01
Patent number
US05484689

Reaction notes

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