HCID 18994252, compound → HCID 18994257, compound

Participants

Reaction Steps

To a suspension of palladium on carbon (1.5 g) in ethanol (30 mL) under N2 was added a solution of 4-[(3-benzyloxy-5-flourophenyl)oxomethyl]-tetrahydropyran (3.7 g, 12 mmol), prepared as in step 6, in ethanol (70 mL). The reaction mixture was flushed three times with hydrogen, was then stirred for three hours under positive hydrogen pressure. The reaction mixture was flushed with N2, filtered through a pad of celite, and concentrated in vacuo to yield 4-[(3-hydroxy-5-fluorophenyl)oxomethyl]tetrahydropyran (2.17 g, 81%) as a white powder which was used without further purification.

Provenance & Evidence