HCID 131719061, compound → HCID 178448459, compound

HRID 375099Notes

Reaction equation

HRID 375099 reaction equation
C(OC(N[C@:7]([CH2:35][CH2:36]CC)([C:15]([N:17]1[CH2:34][CH2:33][CH2:32][C@H:18]1[C:19]([NH:21][C@H:22]([CH:30]=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28])=[O:20])=O)CC1C=CC=CC=1)=O)C.Cl.[CH2:40]([O:42][C:43]([NH:45][C@:46](CCCC)([C:54](N1CCC[C@H]1C(OCC1C=CC=CC=1)=O)=[O:55])[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)=[O:44])[CH3:41]>>[CH2:40]([O:42][C:43]([NH:45][C@H:46]([C:54]([C@@:18]1([C:19]([NH:21][C@H:22]([CH:30]=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28])=[O:20])[CH2:32][CH2:33][CH2:34][N:17]1[CH2:15][CH2:7][CH2:35][CH3:36])=[O:55])[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)=[O:44])[CH3:41]

Participants

3

Reactant 2

HCID 131719061HCID 131719061, compoundHCID 178442357HCID 178442357, compound

Product 1

HCID 178448459HCID 178448459, compound

Procedure

By methods substantially equivalent to those described in Example 17, 1.47 g of EtOCO-Phe(αn-Bu)-Pro-Arg-H·HCl was prepared from EtOCO-Phe(αn-Bu)-Pro-OBzl (TLC Rf =0.74, 50% ethyl acetate:hexanes). EtOCO-Phe(αn-Bu)-Pro-Arg-H·HCl was purified by RPHPLC (98/2 (A/B), 60 min; to 85/15 (A/B), 300 min).

Workup

  1. customEtOCO-Phe(αn-Bu)-Pro-Arg-H·HCl was purified by RPHPLC (98/2 (A/B), 60 min
  2. custom300 min

Sources & evidence

ORD record
ord-d441bea3054648c9a9b42ca718e770b6
Source dataset
uspto-grants-1996_01
Patent number
US05484772

Reaction notes

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