Methyl iodide → HCID 18994409, compound

HRID 375132Notes

Reaction equation

HRID 375132 reaction equation
[OH:1][C:2]1([C:8]2[S:9][C:10]([S:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)=[CH:11][CH:12]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH3:24]I>>[CH3:24][O:1][C:2]1([C:8]2[S:9][C:10]([S:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)=[CH:11][CH:12]=2)[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18994394HCID 18994394, compound

Product 1

HCID 18994409HCID 18994409, compoundYield 81%

Procedure

Using the procedure described in Example 1, 4-hydroxy-4-[5-(naphth-2-ylthio)thien-2-yl]tetrahydropyran was reacted with methyl iodide to give 4-methoxy-4-[5-(naphth-2-ylthio)thien-2-yl]tetrahydropyran in 81% yield, m.p. 70° C.

Sources & evidence

ORD record
ord-9df5df54431f45da9ccdc1f87d4a80b1
Source dataset
uspto-grants-1996_01
Patent number
US05484805

Reaction notes

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