HCID 18994393, compound → HCID 18994424, compound

HRID 375137Notes

Reaction equation

HRID 375137 reaction equation
[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[CH:4]([C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[S:17][C:16]([C:18]3([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)[OH:5].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>>[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([S:12][C:13]2[S:17][C:16]([C:18]3([O:24][CH3:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)=[CH:15][CH:14]=2)=[CH:10][CH:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 18994393HCID 18994393, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 18994424HCID 18994424, compoundYield 71%

Procedure

Using the procedure described in Example 18, 4-[5-(4-(2,4-difluoro-alpha-hydroxybenzyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran was reacted with pyridinium chlorochromate to give 4-[5-(4-(2,4-difluorobenzoyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran in 71% yield, as an oil.

Sources & evidence

ORD record
ord-d888d34fe81e49149512cbb07ea4ae12
Source dataset
uspto-grants-1996_01
Patent number
US05484805

Reaction notes

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