Water → HCID 67655879, compound

HRID 375173Notes

Reaction equation

HRID 375173 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])=[CH:5][CH:4]=1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O>C1(C)C=CC=CC=1>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][C:9](=[CH:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH3:20]

Participants

5

Reactant 3

HCID 962WaterHCID 695242,2-DiethoxyethylamineHCID 10085154HCID 10085154, compound

Product 1

HCID 67655879HCID 67655879, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4'-methoxy-2-[(trifluoromethyl)sulfonyl]acetophenone (6.0 g, 0.021 mol) in toluene is treated with aminoacetaldehyde diethyl acetal (2.8 g, 0.021 mol), heated at reflux overnight with removal of water, and concentrated in vacuo to obtain the title product as an oil. This oil is used in Example 4 without further purification.

Workup

  1. temperatureheated
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5a5438d54e854c13a141a0b60939b54d
Source dataset
uspto-grants-1996_01
Patent number
US05484807

Reaction notes

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