HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 375244Generated: October 29, 2026
3-Pyridinecarboxaldehyde → 4,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one
https://huagongshe.com/reaction/375244
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Amino-6-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one--hydrogen chloride (1/1) | HCID 19036925 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one | HCID 86370 | — |
Reaction Steps
To a suspension of 164 g of 4-amino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine hydrochloride in 500 ml methanol a 50% NaOH solution is added until a pH of 6 is reached. Now 486 g of a solution containing 22% 3-pyridinaldehyde in water is added maintaining a temperature below 70° C. After the addition is completed the reaction mixture is kept at 65° C. for two hours. Then the suspension is cooled to about 5° C., filtered and dried to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05484918 |
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| Source dataset | uspto-grants-1996_01 |
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| ORD ID | ord-5c4ad430db744850bfaf6315dd3a14cc |
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| Source note | uspto-grants-1996_01 |
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