HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-benzhydryloxy-2-oxoethoxy)iminoacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Thiazoleacetic acid, 2-amino-alpha-oxo- | HCID 12783320 | — |
| Reactant | Benzhydryl 2-aminooxyacetate | HCID 23358405 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-benzhydryloxy-2-oxoethoxy)iminoacetic acid | HCID 13729185 | 76.1% |
Reaction Steps
16.5 g of O-diphenylmethoxycarbonylmethylhydroxylamine and 9.9 g of (2-amino-4-thiazolyl)glyoxylic acid are stirred for 3 hours at room temperature in 30 ml of dimethylformamide. The reaction mixture is introduced into 500 ml of methanol, and the resultant deposit is filtered off. 18 g of the title compound are obtained as colourless crystals. M.p.: 125°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484928 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-733546d3950349afa788b8fa4e6a4fe4 |
| Source note | uspto-grants-1996_01 |