4-Methoxy-3-methylcinnamic acid → 155271-40-2

HRID 375312Notes

Reaction equation

HRID 375312 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[CH:27]=[CH:26][C:20]([CH:21]=[CH:22][C:23](O)=O)=[CH:19][C:18]=1[CH3:28]>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:23](/[CH:22]=[CH:21]/[C:20]3[CH:26]=[CH:27][C:17]([O:16][CH3:15])=[C:18]([CH3:28])[CH:19]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 42139864-Methoxy-3-methylcinnamic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448886155271-40-2Yield 38.1%

Procedure

Substantially the same procedure as in Example 7 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 3.00 g (13.9 mmol) of 4-methoxy-3-methylcinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylsulfoxide/water to give 1.70 g (yield 36%) of Compound 110 as white flocculent precipitates.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dimethylsulfoxide/water

Sources & evidence

ORD record
ord-94dcc1e8b0114a1a94f11060e1c86925
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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