5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(3,4-dimethylphenyl)ethenyl)-1,3-dipropyl-, (E)-

HRID 375322Notes

Reaction equation

HRID 375322 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH3:17][C:18]1[CH:19]=[C:20]([CH:26]=[CH:27][C:28]=1[CH3:29])[CH:21]=[CH:22][C:23](O)=O>>[CH3:17][C:18]1[CH:19]=[C:20]([CH:26]=[CH:27][C:28]=1[CH3:29])/[CH:21]=[CH:22]/[C:23]1[NH:1][C:2]2[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedioneHCID 534016643,4-Dimethylcinnamic acid

Product 1

HCID 64487861H-Purine-2,6-dione, 3,7-dihydro-8-(2-(3,4-dimethylphenyl)ethenyl)-1,3-dipropyl-, (E)-

Procedure

Substantially the same procedure as in Reference Example 1 was repeated using 5.90 g (26.0 mmol) of 5,6-diamino-1,3-dipropyluracil and 5.5 g (31.3 mmol) of 3,4-dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 7.70 g (yield of Compound 30 as a white powder.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-824d9e4b7df3422aa85d90f776f89278
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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