3-(3,5-Dimethoxyphenyl)prop-2-enoic acid → 147700-47-8

HRID 375323Notes

Reaction equation

HRID 375323 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:27]=[C:28]([O:30][CH3:31])[CH:29]=1)[CH:22]=[CH:23][C:24](O)=O>>[CH3:31][O:30][C:28]1[CH:27]=[C:21]([CH:20]=[C:19]([O:18][CH3:17])[CH:29]=1)/[CH:22]=[CH:23]/[C:24]1[NH:1][C:2]2[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 860923-(3,5-Dimethoxyphenyl)prop-2-enoic acidHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 5379728147700-47-8Yield 54.2%

Procedure

Substantially the same procedure as in Reference Example 1 was repeated using 3.95 g (17.5 mmol) of 5,6-diamino-1,3-dipropyluracil and 4.0 g (19.2 mmol) of 3,5-dimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylformamide/water to give 3.78 g (yield 54%) of Compound 32 as a white powder.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dimethylformamide/water

Sources & evidence

ORD record
ord-86934c811bd34c34afb3757de2651254
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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