HCID 3126210, compound → 1H-Purine-2,6-dione, 8-[2-(4-butoxyphenyl)ethenyl]-3,7-dihydro-1,3-dipropyl-, (E)-

HRID 375332Notes

Reaction equation

HRID 375332 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH2:17]([O:21][C:22]1[CH:32]=[CH:31][C:25]([CH:26]=[CH:27][C:28](O)=O)=[CH:24][CH:23]=1)[CH2:18][CH2:19][CH3:20]>>[CH2:17]([O:21][C:22]1[CH:23]=[CH:24][C:25](/[CH:26]=[CH:27]/[C:28]2[NH:1][C:2]3[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=3[N:8]=2)=[CH:31][CH:32]=1)[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 3126210HCID 3126210, compoundHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 64488141H-Purine-2,6-dione, 8-[2-(4-butoxyphenyl)ethenyl]-3,7-dihydro-1,3-dipropyl-, (E)-Yield 64%

Procedure

Substantially the same procedure as in Reference Example 1 was repeated using 3.0 g (13.3 mmol) of 5,6-diamino-1,3-dipropyluracil and 3.21 g (14.6 mmol) of 4-butoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 3.47 g (yield 64%) of Compound 51 as white needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-4b9830e8bc414938ac3fc62a58e0a40e
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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