2-Methyl-3-phenylprop-2-enoic acid → 155271-64-0

HRID 375349Notes

Reaction equation

HRID 375349 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][C:16](=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:17](O)=O>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:15](/[C:16](/[CH3:17])=[CH:20]/[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 145412-Methyl-3-phenylprop-2-enoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448910155271-64-0Yield 50%

Procedure

Substantially the same procedure as in Example 7 was repeated using 2.00 g (10.1 mmol) of 5,6-diamino-1,3-diethyluracil and 1.80 g (11.1 mmol) of α-methylcinnamic acid. Then, the resultant crude crystals were recrystallized from ethanol/water to give 1.63 g (yield 50%) of Compound 134 as white needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from ethanol/water

Sources & evidence

ORD record
ord-cafe3f18399248f99ddf8e6a1f0bf24d
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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