5,6-Diamino-1,3-diethyluracil → 155271-74-2

HRID 375354Notes

Reaction equation

HRID 375354 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][CH2:17][O:18][C:19]1[CH:29]=[CH:28][C:22]([CH:23]=[CH:24][C:25](O)=O)=[CH:21][CH:20]=1>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:25](/[CH:24]=[CH:23]/[C:22]3[CH:28]=[CH:29][C:19]([O:18][CH2:17][O:16][CH3:15])=[CH:20][CH:21]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 45721335,6-Diamino-1,3-diethyluracilHCID 541260283-[4-(Methoxymethoxy)phenyl]prop-2-enoic acid

Product 1

HCID 6448920155271-74-2Yield 64.2%

Procedure

Substantially the same procedure as in Example 7 was repeated using 4.00 g (20.2 mmol) of 5,6-diamino-1,3-diethyluracil and 4.62 g (22.2 mmol) of 4-methoxymethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 4.80 g (yield 64%) of Compound 144 as pale yellow needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-79d2d2b435714f129cb38f16f094fc01
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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