3-(4-Fluorophenyl)-2-propenoic acid → 155271-76-4

HRID 375355Notes

Reaction equation

HRID 375355 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16]1[CH:26]=[CH:25][C:19]([CH:20]=[CH:21][C:22](O)=O)=[CH:18][CH:17]=1>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:22](/[CH:21]=[CH:20]/[C:19]3[CH:25]=[CH:26][C:16]([F:15])=[CH:17][CH:18]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 980703-(4-Fluorophenyl)-2-propenoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448922155271-76-4Yield 51%

Procedure

Substantially the same procedure as in Example 7 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.31 g (13.9 mmol) of 4-fluorocinnamic acid. Then, the resultant crude crystals were recrystallized from tetrahydrofuran/water to give 2.00 g (yield 51%) of Compound 146 as colorless columns.

Workup

  1. customThen, the resultant crude crystals were recrystallized from tetrahydrofuran/water

Sources & evidence

ORD record
ord-3aa9b0841af34612996191badedd5ce2
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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