3,5-Bis(trifluoromethyl)cinnamic acid → 155271-78-6

HRID 375356Notes

Reaction equation

HRID 375356 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16]([F:33])([F:32])[C:17]1[CH:18]=[C:19]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH:20]=[CH:21][C:22](O)=O>>[F:15][C:16]([F:32])([F:33])[C:17]1[CH:18]=[C:19]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)/[CH:20]=[CH:21]/[C:22]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 27732123,5-Bis(trifluoromethyl)cinnamic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448924155271-78-6Yield 61%

Procedure

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 4.73 g (16.7 mmol) of 3,5-bis(trifluoromethyl)cinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane to give 4.09 g (yield 61%) of Compound 148 as pale yellow needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane

Sources & evidence

ORD record
ord-45e75212019244eab9d878bbb558fcba
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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