141807-96-7 → 151539-40-1

HRID 375377Notes

Reaction equation

HRID 375377 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])/[CH:6]=[CH:7]/[C:8]1[N:16]([CH3:17])[C:15]2[C:14](=[O:18])[N:13]([CH2:19][CH2:20][CH3:21])[C:12](=[O:22])[N:11]([CH2:23][CH2:24][CH3:25])[C:10]=2[N:9]=1>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])/[CH:6]=[CH:7]\[C:8]1[N:16]([CH3:17])[C:15]2[C:14](=[O:18])[N:13]([CH2:19][CH2:20][CH3:21])[C:12](=[O:22])[N:11]([CH2:23][CH2:24][CH3:25])[C:10]=2[N:9]=1

Participants

3

Reactant 1

HCID 6448585141807-96-7

Product 1

HCID 6448794151539-40-1Yield 57%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 1 (1.00 g, 2.42 mmol) obtained in Reference Example 1 was dissolved in 1.6 L of methanol, and the solution was irradiated with sunlight for 5 hours. After evaporation under reduced pressure, the residue was purified by high performance liquid chromatography (column: YMC Pack ODS-A, SH-365-10, S-10; 30 mmφ×500 mm, flow rate: 90 ml/min, detection: UV 246 nm) to give 565 mg (yield 57%) of Compound 186 as white needles.

Workup

  1. customthe solution was irradiated with sunlight for 5 hours
  2. customAfter evaporation under reduced pressure
  3. customthe residue was purified by high performance liquid chromatography (column: YMC Pack ODS-A, SH-365-10, S-10; 30 mmφ×500 mm, flow rate: 90 ml/min, detection: UV 246 nm)

Sources & evidence

ORD record
ord-a66782b5472449909cc69910d4eab7fb
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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