反应详情

To a solution of 20 g (90 mmol) 2-bromooctanoic acid in 100 mL toluene was added 13.2 mL (180 mmol) thionyl chloride. The solution was heated at reflux under nitrogen for 3 hours. The excess thionyl chloride and toluene were distilled at atmospheric pressure under N2. The yellow residue was purified by kugelrohr distillation (bp=60°-65° C./0.1 mm Hg) and 13.8 g (64%) of the 2-bromooctanoyl chloride as a colorless oil was isolated.

1. temperatureThe solution was heated
2. temperatureat reflux under nitrogen for 3 hours
3. distillationThe excess thionyl chloride and toluene were distilled at atmospheric pressure under N2
4. distillationThe yellow residue was purified by kugelrohr distillation (bp=60°-65° C./0.1 mm Hg)