Morpholine → 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline

Participants

Reaction Conditions

Reaction Steps

A solution of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (0.64 g, 2.5 mmol) and morpholine (0.48 g, 5.5 mmol) in acetonitrile (5 ml) charged in a reaction flask was reacted with tetrafluoroethylene, which was made to flow intothe flask (ca. 0.7 liter/hr), with vigorous stirring at 50° C. for 13 hours. After cooling to an ambient temperature, the reaction solution was poured intoa saturated aqueous sodium hydrogen-carbonate solution (50 ml), and extracted twice with toluene (50 ml×2). The toluene layer was washed twice with 5% hydrochloric acid (30 ml×2) and water (50 ml) and then brine (50 ml), and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was subjected to silica gel column chromatography, which afforded 2-difluoroacetylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (0.64 g, 1.9 mmol, yield 76%).

Provenance & Evidence