Benzaldehyde → HCID 67742168, compound

Participants

Reaction Steps

Pyrazolone from Example 9 (150 mg, 0.31 mmol) was diluted in 5 mL of pyridine in the presence of 2 drops of piperidine and benzaldehyde (32 μL, 0.31 mmol). The reaction mixture was stirred at room temperature for 5 hours. The solvents are evaporated under reduced pressure and the crude material is purified by column chromatography over silica gel eluting with ethyl acetate/hexanes 1:3. The desired material is isolated as a clear oil.

Provenance & Evidence