Phenylacetyl chloride → HCID 67736923, compound

HRID 375425Notes

Reaction equation

Cl.[C:2]1([C:8]2([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH3:24])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]1([CH2:37][C:38](Cl)=[O:39])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:25]1([C:8]2([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH:15]3[C:38](=[O:39])[CH2:37][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH3:24])([OH:17])[CH2:10][CH2:9]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 67736896HCID 67736896, compound

Product 1

HCID 67736923HCID 67736923, compound

Procedure

By working in accordance with the operating method of Example 22 below, starting from 0.68 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methylphenyl)perhydroisoindol- 4-ol hydrochloride and 0.28 cm3 of phenylacetyl chloride, 0.4 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methylphenyl)-2-phenylacetylperhydroisoindol-4-ol is obtained in the form of white crystals which melt at 208° C.

Sources & evidence

ORD record: ord-5f2f4fb49c0a4257a2159fb49ebce9bd
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05484804

Reaction notes

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