HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-(((tert-butoxy)carbonyl)amino)-2-phenylacetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(S)-2-tert-butoxycarbonylamino-2-phenylacetyl]perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-(((tert-butoxy)carbonyl)amino)-2-phenylacetic acid | HCID 11010409 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(S)-2-tert-butoxycarbonylamino-2-phenylacetyl]perhydroisoindol-4-ol | HCID 22857047 | 11.1% |
Reaction Steps
By working in accordance with Example 4, starting from 2.25 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 1.25 g of (S)-2-tert-butoxycarbonylamino-2-phenylacetic acid, 0.35 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(S)-2-tert-butoxycarbonylamino-2-phenylacetyl]perhydroisoindol-4-ol is obtained in the form of a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484804 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-4ecacaa7884848b982d7ee11b68b7b85 |
| Source note | uspto-grants-1996_01 |