HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyphenylacetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyphenylacetic acid | HCID 7134 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]perhydroisoindol-4-ol | HCID 15289536 | 44.1% |
Reaction Steps
By working in accordance with Example 4, starting from 1.13 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.42 g of (2-methoxyphenyl)acetic acid, 0.61 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]perhydroisoindol-4-ol is obtained in the form of white crystals which melt at 204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484804 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-924312d034c24b728f9984221b557de8 |
| Source note | uspto-grants-1996_01 |