HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroindole-3-acetic acid → (3aS,4S,7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroindole-3-acetic acid | HCID 96750 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol | HCID 57167195 | 34.1% |
Reaction Steps
By working in accordance with the operating method of Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.39 g of (5-fluoro-3-indolyl)acetic acid, 0.36 g of (3aS,4S,7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol is obtained in the form of white crystals which melt with decomposition at 170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484804 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-a1ddaaea3e874fcba24b6cc92f6c39fe |
| Source note | uspto-grants-1996_01 |