HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-methyl-1H-indol-3-yl)acetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1-methyl-3-indolyl)acetyl)perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-methyl-1H-indol-3-yl)acetic acid | HCID 254166 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1-methyl-3-indolyl)acetyl)perhydroisoindol-4-ol | HCID 67736900 | 58% |
Reaction Steps
By working in accordance with Example 4, starting from 0.75 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.32 g of (1-methyl-3-indolyl)acetic acid, 0.56 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1-methyl-3-indolyl)acetyl)perhydroisoindol-4-ol is obtained in the form of a beige foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484804 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-93ef3e073b9040b282b12ba49420ed55 |
| Source note | uspto-grants-1996_01 |